The question of why we age is one of the most fascinating questions for humankind, but nothing close to a satisfactory answer has been found to date. Scientists have now taken one step closer to providing an answer. They have conducted a study in which, for the first time, they have shown that a certain area of the cell, the so-called endoplasmic reticulum, loses its oxidative power in advanced age. If this elixir of life is lost, many proteins can no longer mature properly. At the same time, oxidative damage accumulates in another area of the cell, the cytosol. This interplay was previously unknown and now opens up a new understanding of aging, but also of neurodegenerative diseases such as Alzheimer’s or Parkinson’s.